Background: Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of clonal plasma cells in the bone marrow, leading to severe systemic complications. Despite advancements in its diagnosis and treatment, MM remains a significant public health concern due to its chronic nature and complex treatment regimens. Awareness and understanding of MM among the general population are critical for early diagnosis, effective management, and improved patient outcomes. This study aims to assess the awareness and knowledge about MM among adults in District Ambala, Haryana, India. Materials and Methods: A descriptive research approach with a cross-sectional survey design was utilized. The study was conducted in District Ambala, Haryana, between January 2024 and May 2024. The target population included adults aged 18 and above who had been residents of District Ambala for at least 12 months. A sample size of 400 adults was determined using a 95% confidence level, an estimated knowledge level of 50%, a 5% absolute error margin, and a 5% non-response rate. Data were collected using a Google form questionnaire comprising socio-demographic and MM-related knowledge questions. The questionnaire was pre-tested for clarity and validated by experts. Data were analyzed using Microsoft Excel and Epi Info V7 software, with appropriate statistical tests for frequencies and percentages. Results: The study collected data from 400 participants. The age distribution showed a balanced representation across various age groups, with a slight male predominance (55.8%). The majority of participants were married (54.0%) and primarily Hindu (69.8%). Employment status varied, with 52.5% employed, 24.5% students, and 23.0% unemployed. Knowledge assessment revealed high awareness of MM's basic understanding (71.8%), curability (69.3%), and diagnostic steps (70.8%). However, lower awareness was noted for the stages of MM (42.3%), bone marrow transplant roles (40.0%), and new treatment advancements (41.3%). Overall, 23.3% of participants had very good knowledge, while 30.3% had fair knowledge, and 19.8% had poor knowledge. Significant associations were found between knowledge levels and socio-demographic factors such as age, gender, marital status, religion, employment, and education. Conclusion: The study highlights critical knowledge gaps in the public's understanding of MM, particularly in specific aspects of the disease. These gaps necessitate targeted educational interventions. Socio-demographic factors significantly influence knowledge levels, indicating the need for tailored public health strategies to enhance MM awareness and understanding. Improving public awareness can lead to better early diagnosis, management, and outcomes for MM patients in District Ambala, Haryana.