Multiple recent studies have found metabolic syndrome (MS) to be associated with chronic infections like hepatitis B. Very few studies have been reported from India. The current study is aimed to identify any relationship between MS and chronic hepatitis B infection. Materials: 47 treatment naïve CHB patients and 50 age and sex matched controls with age more than 18 years were included in the study. Metabolic syndrome was defined using NCEP-ATP III 2004 criteria. Chronic hepatitis B (CHB) was diagnosed by the presence of HBsAg and anti-hepatitis B core antibody (IgG). Patients were clinically evaluated and biochemical estimation, ultrasound abdomen, HBV DNA were done in every patient. Exclusion criteria included chronic hepatitis other than hepatitis B, concomitant HIV/HCV coinfection, chronic inflammatory disease like RA and patients on lipid lowering drugs. Observation’s: Out of 47 cases, 9 had MS (19.1%vs 20% in control). CHB patients had lower mean total cholesterol (126.34±43.97 mg/dL vs 155.3±42.4 mg/dL P=0.001), lower mean triglyceride (109.04±40.75 mg/dL vs 136.33±60.88 mg/dL, P=0.01), lower mean HDL level (25.25±12.05 mg/dL vs 35.61±11.47 mg/dL, P<0.001) level than controls. Out of 9 patients who had metabolic syndrome, 5(20.83%) had HBV DNA above median (82200 IU/mL). Conclusion: Current study found a lower incidence of MS in CHB infection with significantly lower level of TC, HDL-C and TGL; Higher DNA load was associated with lesser incidence of MS.