Palmoplantar keratodermas (PPK) form a category of disorders typified by disproportionate epidermal thickening of the palms and soles. PPK may be inherited or acquired. The mutations in genes encoding different proteins involved in keratinization process are involved in the pathogenesis of inherited PPK. Majority of patients of inherited PPK manifest in infancy. Vorner's keratoderma and Unna-Thost keratoderma are two major types of non-transgradient diffuse palmo-planter keratoderma inherited as autosomal dominant trait. They are clinically similar but histologically there are minute differences. We are presenting here a case of mother and a child with thickening of palms and soles. The final diagnosis was made after the histopathological examination.