Cardiovascular diseases (CVDs) pose a significant health threat globally, including the northern hilly state of Himachal Pradesh, India. Effective cardiopulmonary resuscitation (CPR) is crucial in responding to sudden cardiac arrests, given the challenging terrain and limited healthcare access. This study aimed to assess the CPR knowledge among medical officers in Himachal Pradesh. Methods: A descriptive cross-sectional survey was conducted among 100 medical officers in Himachal Pradesh from April 2023 to July 2023. A Google Form questionnaire was used to collect data on CPR knowledge, and scoring was categorized as very good, good, fair, or poor. Data analysis was performed using Epi Info V7 software.Results: The study revealed that 31% of medical officers had very good CPR knowledge, 37% had good knowledge, 22% had fair knowledge, and 10% had poor knowledge. While a substantial portion demonstrated proficiency, a notable proportion exhibited knowledge gaps in CPR techniques. Conclusion: Although many medical officers in Himachal Pradesh displayed commendable CPR knowledge, disparities were evident, emphasizing the need for standardized training programs and regular refresher courses. Bridging knowledge gaps and enhancing CPR competence is essential for improving cardiac care and patient outcomes.