A descriptive and retrospective study was conducted in the hospital, which included all age groups with a clinical diagnosis between January 1, 2019, and June 30, 2020. Ninety patients were collected from AL-Hussein Medical City, Karbala, Iraq, where the study aims to describe the clinical and epidemiological profile of patients with diseases. Bullous pemphigoid is an autoimmune skin disease that occurs mainly in the elderly. It is estimated that it affects between seven and thirteen people per million. Neurological symptoms often start very subtly, and the onset of autoimmune diseases may contribute to a delay in neurological diagnosis", who consider it reasonable to speculate that some neurological disorders may predispose to bullous pemphigoid. “The association between bullous pemphigoid and neurodegenerative disease has been the subject of several prominent clinical cases, but a subset of these patients has not been characterized. We have shown a significant association between the two and that neurodegenerative disease can be a predisposing factor. Pemphigus can coexist with central nervous system disorders, particularly dementia, epilepsy, and Parkinson's disease. It is present in CNS neurons (and in all epithelial cells), and an immune cross-reactivity between CNS and epithelial isoforms has been suggested.