Background: The present study was done for comparative evaluation of change in intra cuff pressure using Ambu Auragain in Trendelenburg and Reverse Trendelenburg Position in patients undergoing Laparoscopic Surgery. Material & Methods: This was a prospective cohort study conducted on 46 patients in Department of Anaesthesia to determine intra cuff-pressure in laparoscopic surgeries in Trendelenburg and Reverse Trendelenburg position with the use of Ambu AuraGain. Group A included 16 patients with Trendelenburg position and Group B included 30 patients with Reverse Trendelenburg position. Results: The mean age of patients in Group A was 44.44±11.11years whereas the mean age of patients in Group B was 45.50±11.78years (p>0.05). Group A comprised of 2 (12.5%) males and 14 (87.5%) females whereas Group B comprised of 12 (40%) males and 18 (60%) females (p>0.05). The mean BMI of patients in Group A was found to be 22.28±1.58kg/m2 and mean BMI of patients in Group B was 22.57±2.54kg/m2 (p>0.05). Group A comprised of 11 (68.8%) patients with ASA status I and 5 (31.2%) patients with ASA status II. On the other hand, Group B had 15 cases each with ASA status I and II (p>0.05). The average duration of surgeries in Group A was 80-90 minutes whereas the average duration of surgeries in Group B was 70-80 minutes.The baseline Cuff Pressures were comparable in Group A and Group B. The comparison between mean cuff pressure of two groups was found to be statistically significant at all recorded time intervals except after SGA placement, and before CO2 insufflation (p>0.05). Cuff pressure was higher in Group A than Group B. Only 2 patients in Group A and no patient in Group B required intervention by release of air with the help of cuff manometer. This was not found to be statistically significant (p>0.05). Conclusion: We found in this study that Trendelenburg or Head down position increases intra cuff pressure peak airway pressure as compared to Reverse Trendelenburg position. So it is recommended to monitor intra cuff pressure of SGA frequently in laparoscopic surgeries.